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Hematologist

Sickle cell disease treatment in India.

What is Sickle cell disease?

Sickle cell anemia is a severe form of anemia caused by genetic mutation in the Red blood cells. It is a genetic disorder which is inherited by the patient from the two faulty hemoglobin genes from both the parents. Because of the genetic mutation,the shape of RBC ,which is flexible circular disc shaped changes to rigid sickle or crescent shaped rods. Hemoglobin a protein in RBCs,works as a transporter of nutrients and oxygen to cells all across the body.Normal RBCs are disc shaped,with the centers partially scooped out. They are flexible and soft and therefore have the capacity to squeeze through even the tiniest of blood vessels to reach every cell in the body.Due to genetic mutation the RBCs acquire the shape of a crescent moon or Sickle and become rigid and brittle.These Abnormal shaped RBCs which are not flexible get struck in small blood vessels causing slow or blockage of blood flow to other tissues of body and disrupt supply of Oxygen to those parts. Moreover the lifespan of abnormal sickle shaped RBCs is only 10-20 days as compared to 120 days of normal RBCs.Human body keeps on forming new RBCs to replace the old ones,but in a person with sickle cell disease the balance in formation of new RBCs and Destruction of existing RBCs is disturbed. This results in lower RBC count or anemia in a person suffering with Sickle cell disease.

What are complications of Sickle cell disease?

Sickle cell anemia may have different complications in different people at different stages of disease,but the major and severe complications for a person suffering from sickle cell anemia can be broadly classified as Acute and chronic.

Acute Complication:

Sickle cell crisis:

Sickle cell crisis or VAS ( Vaso occlusive crisis ) manifests as acute severe pain.Sickle cells disrupts blood supply through smaller capillaries resulting in ischemia. Sudden pain across body that may persist from a few hours to a few days.The pain usually occurs in limbs,chest and back.

Fever and infections:

Patients with sickle cell disease are prone to severe bacterial infections because of reduction or absence of splenic function. This may expose the patient to extremely high risk of septicemia and meningitis.Pneumonia is the most common infection ,meningitis,influenza and hepatitis are other infections occurring in sickle cell disease patients.

A Stroke:

Sickle cell disease may cause a a stroke in an affected person because of oxygen deprivation due to blockage in supply of blood to tissue of brain. Some of the sickle cell anemia patients may experience a Transient ischemic attack.

Acute Chest Syndrome:

Pneumonia like complications in a child or adult suffering from sickle cell disease. The reason could be an infection or sickle cells trapped in micro capillaries of lungs.

Hepatobiliary complications:

Hepatobiliary tract abnormalities are common in sickle cell disease patients.They may include cholelithiasis, acute cholecystitis, biliary sludge, and acute choledocholithiasis,acute Hepatic Sequestration and acute intrahepatic cholestasis.

Acute renal failure:

A decrease in kidney functions due to dehydration or obstruction or even because of intrinsic renal disease.

Acute Anemia:

May be because of Splenic sequestration.

Multisystem Organ failure:

A systemic failure of lungs,liver and kidney is a life threatening medical condition for sickle cell anemia patients.

Chronic Complications:

Vision Problems:

A sickle cell disease patient may develop vision problems over a period of time.It may include proliferative sickle retinopathy and vitreous hemorrhage. Complete vision loss is also possible.

Avascular Necrosis:

Avascular or aseptic necrosis can occur when capillaries are occluded by sickled erythrocytes at distal portions of a bone, near a joint, where hypoxia is maximal and collateral circulation is inadequate .The most common site for sickle cell anemia induced avascular necrosis is femoral neck.

Leg Ulcers:

Leg ulcers appear in patients of sickle cell anemia.

Pulmonary Hypertension:

Pulmonary hypertension occur in sickle cell disease patients.

Sickle cell anemia-Treatments:

Sickle cell anemia patients are usually referred to a Hematologist ( A doctor who has specialized in blood disease management). Treatment of sickle cell anemia may involve determining many factors by the treating hematologist.Treatment of sickle cell anemia includes regular monitoring and follow up with a hematologist,Medications for management of symptoms and complications,pain management,blood transfusions, oxygen supplementation and allogeneic Bone Marrow transplant.

Stem Cell or BMT for Sickle cell disease

Stem cell or Bone marrow transplant is a viable treatment option for those young sickle cell anemia patients where the diseases condition is severe and can not be managed with conventional methods. A sickle cell anemia child who is having a matching sibling donor is referred for a bone marrow transplant by the hematologist considering all the pros and cons. Risk involved is big but a stem cell or bone marrow transplant is the only cure for sickle cell anemia child or young adult.

Before the transplant, bone marrow cells  are taken from a close matching healthy brother or sister. The patient with sickle cell disease is then treated with chemotherapy and radiation that destroy his or her bone marrow cells. After that, the donated bone marrow stem cells are transplanted in the patient.

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Multiple Myeloma – Treatment in India.

Multiple Myeloma Treatment In India

Multiple Myeloma is a diseased medical condition involving plasma cells. Normal plasma cells are found in the bone marrow and form an integral God gifted immune system for a healthy Individual.

At CMCS Health we are associated with Best Hematologist and BMT specialist from India for cost effective treatment of hematological malignancies in India. We Offer cost effective Multiple Myeloma -  Treatment in India for our Global guests seeking specialized medical treatment in India.

What is Multiple Myeloma:

Multiple Myeloma is a diseased medical condition involving plasma cells. Normal plasma cells are found in the bone marrow and form an integral God gifted immune system for a healthy Individual.

In Multiple Myeloma patients the normal plasma cells are converted into Malignant plasma cells. These Myeloma plasma cells produce large quantities of abnormal immunoglobulins called M Protien.

The large quantities of this abnormal immunoglobulin hampers the production of normal blood cells in Multiple myeloma patients.

Symptoms of Multiple Myeloma:

Although many of the patients suffering from multiple myeloma may not exhibit or feel any symptoms and it is diagnosed because of some lab. tests recommended by a clinician for other health complaints of the patients.

The common symptoms of Multiple myeloma experienced by patients are:

  • Pain in bones ,which could be in all skeleton system but more prominent in skull,back or hips. Patients of multiple myeloma can easily fracture their bones even with a slight stress or injury because of weakening of bone (osteoporosis ) either in the entire skeletal system or at a place of plasmacytoma.
  • A routine CBC recommended by a physician to rule out a health complaint reveals low RBC , WBC and platelets.Low RBCs cause fatigue , a general feeling of malice and not being well, difficulty in breathing and dizziness. Low WBCs will make patient prone to frequent infections and some patient may have pneumonia. Low blood platelet count may culminate  in delayed blood clotting time and excessive bleeding even with a minor cut or bruise .
  • Hypercalcemia or excess calcium in blood may cause extreme thirst and drinking of plenty of fluids and frequent urinating, dehydration,kidney problems,severe constipation, loss of appetite ,a feeling of drowsiness and confusion.
  • Spinal cord compression in multiple myeloma patient because of weakening of bones and collapsing of spinal vertebrae may cause muscle weakness and numbness in legs or sudden severe back pain.
  • Other more severe symptoms may include congestive heart failure, enlarged liver and spleen ,enlarged tongue ,skin changes, persistent diarrhoea and numbness and weakness in hands called carpal tunnel syndrome.

Diagnosis Of Multiple Myeloma:

Once a clinician suspects that a patient is having multiple myeloma ,he recommends certain blood ,urine , a bone marrow biopsy , Xrays ,CT scans and MRIs to confirm the diagnosis.

 Multiple Myeloma - Treatment in India:

The treatment of multiple myeloma depends on staging done by a hematologist. Usually treatment of multiple myeloma consists of chemotherapy and supportive care , radiation therapy ,surgery in certain cases and Bone Marrow or Stem cell Transplant.

BMT or Stem Cell Transplant for Multiple Myeloma:

 

Follow up Post Multiple Myeloma Treatment:

 

 

Dr. Pawan Kumar Singh - Blood Cancer | BMT specialists is well qualified and well trained in field of Hemato Oncology and Bone Marrow Transplant among Indian clinical hematologists.

Dr Pawan Kumar Singh currently heads the Hematology and Bone Marrow Transplantation department at Artemis Hospital in Gurgaon, India

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Bone Marrow Transplant In India | Best medical tourism Company In India

Bone Marrow Transplant in India -Blood cancer Treatment in India

Bone Marrow Transplant In India-or Hematopoietic stem cell transplant for Blood cancers is a viable option for treating certain Hematological Malignancies.

We at CMCS Health are associated with best Bone Marrow Transplant Specialist Doctors in India  and well equipped medical centers for conducting successful Bone Marrow Transplant- Blood cancer treatments in India.

Bone Marrow Transplant In India | Best Bone Marrow Transplant Surgeon In India

Dr. Vikas Dua  is widely regarded as one of the best bone marrow transplantation specialists and clinical hematologists of his generation by virtue of his excellent patient outcomes that have consistently been among the very best in his field in India and abroad.

Dr vikas Dua  CV lists his impressive training credentials. After an initial 2-year stint at the Christian Medical College, Vellore, a center widely regarded as the cradle of hematology and bone marrow transplantation in India under the famed Prof. Mammon Chandy, he moved to the All India Institute of Medical Sciences,

Bone Marrow Transplant In India |Best Blood cancer Treatment In India

New Delhi, India for a formal 3-year superspecialist degree of DM in Clinical Hematology. At AIIMS he trained under renowned names like Professors Rajat Kumar, VP Chaudhry and Renu Saxena. Subsequently,

Dr. Vikas dua  was selected for a fellowship in Vancouver, Canada and underwent specific training in voluntary stem cell and umbilical cord transplantation.

Upon his return to India, he joined the Medanta Medicity, Gurgaon, India . He developed its bone marrow transplantation and hematology services from the ground-up,

Bone Marrow Transplant In India

achieving a remarkable 100 transplants in a period of  36 months in the then new hospital that soon became one of the largest medical centres in the country.

Dr. Bhargava currently heads the Hematology and Bone Marrow Transplantation department at the Artemis Hospital in Gurgaon, India. The department has its own transplantation unit and extensive laboratory facilities,

Blood cancer Treatment In India

providing cutting-edge clinical skills and the latest in technology at affordable costs for transplantation and other hematological services.

His fame attracts patients not only from all parts of India but also from Pakistan, Bangladesh, Nepal, Bhutan, Africa, Iraq and Russia among others. Till date,

Dr. Rahul Bhargava has performed close to 200 adult bone marrow transplants which is record-breaking in whole of North India.

Bone Marrow Transplant IN India - Best BMT Surgeon In India

BMT is replacement of abnormal or damaged bone marrow in a person by healthy bone marrow. Bone marrow transplant is also known as stem cell transplant. Stem cells are undifferentiated biological cell that has ability to develop in differentiated biological cells.

Bone marrow transplant are life saving medical intervention for saving lives of people suffering from abnormal and damaged bone marrow stem cell ,giving rise to diseased medical conditions which can be both malignant or cancerous and non malignant or non cancerous.

Blood Cancer Treatments in India-Bone marrow transplant In India

Blood cancers or Hematological malignancies requiring Bone Marrow transplants are:-

Leukemia, Multiple Myeloma and myelodysplasia.

Non Cancerous medical conditions requiring bone marrow transplants are : Aplastic anemia and Hemoglobinopathies.

Bone marrow transplants can be classified as:

Autologuos bone marrow transplant where patients own bone marrow cells are infused back and Allogenic bone marrow transplant where the bone marrow stem cells are procured from a donor.

At Complete Medicare Solutions, We are associated with Best Indian Hematologist and Bone Marrow Transplant Specialists. A bone marrow transplant requires a highly upgraded and well equipped medical center as the risk of life-threatening infections are high with BMT procedures. At Complete Medicare Solutions we have selected best Indian hospitals which are well equipped and well managed for risk-free BMT procedures for our Global guests.

What patients and Attendants Need to know before BMT:

Like any other organ transplant, bone marrow transplants may be associated with serious risks; the treating doctors will help the patient and attendant in considering pros and cons of going for a bone marrow transplant.

BMT is definitely a life-saving condition for many patients. Selection of a suitable donor is very important for the success of BMT.HLA tests determine how the antigens of recipient’s stem cells matches to antigens of donor’s stem cell.

The higher the number of  matching HLA antigens ,the greater are chances of recipient’s body accepting the donor stem cells. Close relatives like brothers and sisters of recipient have better chances of matching HLA antigens and thereby successful BMT procedures as compared to a non related donor.

What is ideal time to do BMT for patients with Blood cancer :

The ideal time to do BMT with good success rate is when the disease is in remission ( The signs and symptoms are not present usually after completion of chemotherapy cycles) and in early stage of disease, children and generally good health of patient.

Bone Marrow Transplant IN India

Chemotherapy induced hepatotoxicity .Conditioning induced neutropenia and thrombocytopenia resulting in infections, bleeding and mucositis.

Approximately within 4 weeks of BMT ,signs of engraftment start appearing. When the patient is found fit to be discharged post successful BMT,patient is discharged from hospital but proper follow up medical care is advised by the doctors post discharge.

 

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